A wide selection of Cas nucleases are available under the Cas Type filter
One of the many draws and advantages of using the CRISPR/Cas nuclease system for gene manipulation is its flexibility and applicability across a wide array of systems, organisms, and experiments. Thus, in addition to filters for Application (e.g. CRISPR knockdown, knockin, etc.), you can also filter for specific Cas Types to find the one with the desired nuclease activity and PAM (protospacer adjacent motif) sequence. Find the Cas Types filter under Cas Nuclease specs. Your choices include:
Cas9 (aka SpCas9)
Blunt-ended dsDNA break. gRNA spacer length ~18-24 nt.
Cas9 null (aka SpCas9 null)
Engineered not to cut DNA. May be used for targeting.
Creates a single stranded cut. May be used with two adjacent sgRNAs to reduce off-target effects.
Blunt-ended dsDNA break. Similar to SpCas9 in use.
Engineered not to cut DNA.
Cas12a (aka Cpf1)
May target and cleave single stranded DNA. Cas12a may also leave 5’ overhang after cleavage.