Finding RNAi products with modifications to improve outcomes
Sense strand modifications are one in a slew of effective strategies in RNAi design to reduce off-target interactions or otherwise generally improve experiment outcomes. Examples are 2’-OMe and phosphorothioate modifications. Some of these modifications (and others) are central to certain brands and vendors, so if you are looking for specific sense strand modifications, try filtering for companies that specialize in them while we work on new filters.
If RNAi strand modifications are an important feature in the reagents you use, we’d love to talk to you about it.