Learning more about RNAi sequences on BenchSci

Reagent Platform: BenchSci can now identify and extract sequences for RNAi reagents from scientific publications. Available to select groups.

BenchSci has made the next leap in empowering you to run better, more successful experiments. Building on the technologies and approaches we pioneered for the antibody platform, our advanced AI can now identify the use of RNA interference reagents in genetic manipulation experiments and extract those sequences from the literature. These advances capture more custom products, allowing you to discover critical information on a broader range of RNAi reagents.

Not all scientific publications include a full product citation with vendor and catalog information for RNAi products used in the research, particularly when reagents are developed in-house. To address this, we trained our AI to comb through the text in search of the RNAi sequences referenced in figures. The relative ease of generating bespoke RNAi reagents means that having the sequence information is no less meaningful than a vendor catalog number. This is a powerful and invaluable use of our machine learning algorithms, allowing you to identify sequences that are likely to succeed in knockout and knockdown experiments with greater confidence.

Our AI is always improving at better understanding the different ways that scientists write about RNAi sequences, however we recommend clicking out to the original publication when you find a sequence you like. This gives you the opportunity to learn if the sequence is for a siRNA, shRNA, or miRNA and to verify the sequence. 

Following aSee Sequence Details link takes you to a sequence page that aggregates the data we have, including the cell lines studied and other figures that used the sequence. See below for a brief demonstration of navigating the RNAi sequence info!